Metabolic Consequences of Gut Dysbiosis in Dogs with IBD
- Jan S. Suchodolski, MedVet, DrMedVet, PhD, DACVM, AGAF
- Texas A&M University
- Gut dysbiosis (microbial imbalance) causes metabolic abnormalities, such as altered bile acid metabolism, which increases inflammation and can exacerbate or cause inflammatory bowel disease (IBD) in dogs.
- Although antibiotic administration can be useful in treating IBD and other GI mdiseases, chronic use disrupts the microbial ecosystem and can lead to dysbiosis, altered bile acid metabolism, and increased oxidative stress (free radical damage).
- With more research into the microbiota, metabolome and the host response, we will have a clearer understanding of how to develop more effective therapies for IBD for our pets.