Metabolic Consequences of Gut Dysbiosis in Dogs with IBD

Jan S. Suchodolski, MedVet, DrMedVet, PhD, DACVM, AGAF
Texas A&M University

 

KEY FINDINGS:

  • Gut dysbiosis (microbial imbalance) causes metabolic abnormalities, such as altered bile acid metabolism, which increases inflammation and can exacerbate or cause inflammatory bowel disease (IBD) in dogs.
  • Although antibiotic administration can be useful in treating IBD and other GI mdiseases, chronic use disrupts the microbial ecosystem and can lead to dysbiosis, altered bile acid metabolism, and increased oxidative stress (free radical damage).
  • With more research into the microbiota, metabolome and the host response, we will have a clearer understanding of how to develop more effective therapies for IBD for our pets.

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SPEAKER BIOGRAPHY

Jan S. Suchodolski, MedVet, DrMedVet, PhD, DACVM, AGAF- Texas A&M University

Dr. Jan Suchodolski graduated with a veterinary degree from the University of Veterinary Medicine in Vienna, Austria, in 1997. After working several years in a small animal specialty clinic, he returned to academia and received his doctor of veterinary medicine degree from the University of Vienna, Austria, in recognition for his research on a potential diagnostic marker for canine gastric disease. In 2005, Dr. Suchodolski received his doctorate in veterinary microbiology from Texas A&M University for his work on molecular markers for the assessment of the intestinal microbiota. He is board-certified in immunology by the American College of Veterinary Microbiologists, and currently serves as associate professor and associate director for research and head of microbiome sciences at the GI Lab at Texas A&M University.

“There is mounting evidence that microbiota dysbiosis is linked with metabolic changes in dogs and cats with GI disease.”