Daniel E.L. Promislow - The Dog Aging Project: Can Old Dogs Teach Us New Tricks?

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Daniel E.L. Promislow

Daniel E.L. Promislow, DPhil, University of Washington dept. of Pathology, Dept. of Biology

Dr. Daniel Promislow began working on the evolution of aging over 30 years ago as a graduate student at the Univer­sity of Oxford. Following postdoctoral work in France and Canada, he spent 18 years in the Department of Genetics at the University of Georgia. In 2013, he moved to the University of Washington, where he currently is a professor in the Departments of Biology and Pathology. Throughout his career, Dr. Promislow has focused on the biology of aging and age-related disease. In particular, his work addresses the challenge of understanding how genes and the environ­ment shape patterns of aging in natural populations, using theoretical models, epidemiological analysis and empirical studies. His laboratory is funded by grants from the National Institutes of Health, the National Science Foundation and the Glenn Foundation for Medical Research. About 10 years ago, Dr. Promislow began epidemiological studies of aging in companion dogs. He is especially interested in studying the ways an organism’s biology can be measured through high-throughput molecular biology, particularly the “epig­enome,” the “microbiome” and the “metabolome,” and when combined with statistical models of network interac­tions can help us to better understand how genetic variation gives rise to variations in behavior, morphology and ultimately life span and the risks of age-related disease. As co-director and principal investigator of the Dog Aging Project, Dr. Promislow leads a large interdisciplinary team creating a nationwide long-term study of aging in 10,000 companion dogs, with a goal of understanding how genes and the environment shape healthy aging.

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