1. Cupp, C. J., Kerr, W.W., Jean-Philippe, C., Patil, A. R., & Perez-Camargo, G. (2008). The role of nutritional interventions in the longevity and maintenance of long-term health in aging cats. International Journal of Applied Research in Veterinary Medicine, 6(2), 69-81. 

2. Kealy, R.D., Lawler, D.F., Ballam, J. M., Mantz, S. L., Biery, D. N., Greeley, E.H., … Stowe, H.D. (2002). Effects of diet restriction on life span and age-related changes in dogs. Journal of the American Veterinary Medical Association. 220, 1315-1320.

3. Penell, J. C., Morgan, D. M., Watson, P., Carmichael, S., & Adams, V. J. (2019). Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs. Acta Veterinaria Scandinavica, 61(1), 42.

4. Freeman, L. M. (2012). Cachexia and sarcopenia: Emerging syndromes of importance in dogs and cats. Journal of Veterinary Internal Medicine, 26, 3-17.­

5. Datz C. A. (2010). Noninfectious causes of immunosuppression in dogs and cats. The Veterinary clinics of North America. Small animal practice, 40(3), 459-467.

6. Laflamme, D. P. (2013). Protein requirements of aging cats based on preservation of lean body mass. Proceedings of the 13^th Annual AAVN Symposium (17). Washington, USA. 

7. Laflamme, D. P., & Hannah, S. S. (2013). Discrepancy between use of lean body mass or nitrogen balance to determine protein requirements for adult cats. Journal of Feline Medicine and Surgery, 15(8), 691–697.

8. Wannemacher, R.W., &  McCoy, J.R. (1966). Determination of optimal dietary protein requirements of young and old dogs. Journal of Nutrition, 88(1), 66-74.

9. Perez-Camargo, G., Patil, A. R., & Cupp, C. J. (2004). Body composition changes in aging cats. Compendium on Continuing Education for the Practicing Veterinarian, 26(Suppl 2A), 71. 

10. Cupp, C. J., & Kerr, W.W. (2010). Effect of diet and body composition on life span in aging cats. (2010). Nestlé Purina Companion Animal Nutrition Summit (36-42). Florida, USA. 

11. Laflamme, D.P., & Hannah, S.S. (2005). Increased dietary protein promotes fat loss and reduces loss of lean body mass during weight loss in cats. International Journal of Applied Research in Veterinary Medicine, 3(2), 62-68. 

12. Hannah, S.S. & Laflamme, D.P. (1998). Increased dietary protein spares lean body mass during weight loss in dogs. Journal of Veterinary Internal Medicine, 12, 224.

13. Laflamme, D.P. (1997). Development and validation of a Body Condition Score System for Cats: A clinical tool. Feline Practice, 25, 5-6, 13-18.

14. Laflamme, D.P. (1997). Development and validation of a Body Condition Score System for Dogs. Canine Practice, 22(4), 10-15.

15. Bjornvad, C.R., Nielsen, D.H., & Armstrong, P.J. (2011). Evaluation of a nine-point body condition scoring system in physically inactive pet cats. American Journal ofVeterinary Research, 72(4), 433-437.  

16. German, A.J., Holden, S.L., Moxham, G.L., Holmes, K.L., Hacket, R.M., & Rawlings, J. M. (2006). A simple, reliable tool for owners to assess the body condition of their dog or cat. Journal of Nutrition, 136(7), 2031S-2033S. 

17. Mawby, D.I., Bartges, J.W., D'Avignon, A., Laflamme, D.P., Moyers, T.D., & Cottrell, T. (2004). Comparison of various methods for estimating body fat in dogs. Journal of the American Animal Hospital Association, 40(2), 109-114.

18. Freeman, L. M., Sutherland-Smith, J., Cummings, C., & Rush, J. E. (2018). Evaluation of a quantitatively derived value for assessment of muscle mass in clinically normal cats. American Journal of Veterinary Research, 79(11), 1188-1192.

19. Freeman, L. M., Michel, K. E., Zanghi, B. M., Vester Boler, B. M., & Fages, J. (2019). Evaluation of the use of muscle condition score and ultrasonographic measurements for assessment of muscle mass in dogs. American Journal of Veterinary Research, 80(6), 595-600.

20. Michel, K. E., Anderson, W., Cupp, C., & Laflamme, D. P. (2011). Correlation of a feline muscle mass score with body composition determined by dual-energy X-ray absorptiometry. The British Journal of Nutrition, 106 Suppl 1, S57-S59.

1. Fontana, L., Partridge, L., & Longo, V. D. (2010). Extending healthy life span--from yeast to humans. Science (New York, N.Y.), 328(5976), 321-326.

2. Kaeberlein, M., Creevy, K. E., & Promislow, D. E. (2016). The dog aging project: translational geroscience in companion animals. Mammalian genome: official journal of the International Mammalian Genome Society, 27(7-8), 279-288.

3. Kealy, R.D., Lawler, D.F., Ballam, J.M., Mantz, S.L., Biery, D.N., Greeley. E.H., & Stowe, H.D. (2002). Effects of diet restriction on life span and age-related changes in dogs. Journal of the American Veterinary Medical Association, 220, 1315-1320.

4.  Lawler, D.F., Larson, B.T., Ballam, J.M., Smith, G.K., Biery, D.N., Evans, R.H., & Kealy, R.D. (2008). Diet restriction and ageing in the dog: major observations over two decades. British Journal of Nutrition, 99(4), 793-805.

5. Smith, G. K., Paster, E. R., Powers, M. Y., Lawler, D. F., Biery, D. N., Shofer, F. S., McKelvie, P. J., & Kealy, R. D. (2006). Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs. Journal of the American Veterinary Medical Association, 229(5), 690-693.

6. Kealy, R.D., Lawler, D.F., Ballam, J.M., Lust, G., Biery, D.N., Smith, G.K., & Mantz, S.L. (2000). Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. Journal of the American Veterinary Medical Association, 217(11), 1678-1680.

    Altri lavori di ricerca attinenti a questo studio durato 14 anni: 

6.1. Huck, J. L., Biery, D. N., Lawler, D.F., Gregor, T. P., Runge, J. J., Evans, R.H., Kealy, R.D., & Smith, G. K. (2009). A longitudinal study of the influence of lifetime food restriction on development of osteoarthritis in the canine elbow. Veterinary Surgery, 38(2), 192- 198.

6.2. Greeley, E. H., Kealy, R.D., Ballam, J. M., Lawler, D. F., & Segre, M. (1996). The influence of age on the canine immune system. Veterinary Immunology and Immunopathology, 55(1-3), 1-10.

6.3. Greeley, E.H., Ballam, J.M., Harrison, J.M., Kealy, R.D., Lawler, D.F., & Segre, M. (2001). The influence of age and gender on the immune system: a longitudinal study in Labrador Retriever dogs. Veterinary Immunology and Immunopathology, 82(1-2), 57-71.

6.4. Greeley, E.H., Spitznagel, E., Lawler, D.F., Kealy, R.D., & Segre, M. (2006). Modulation of canine immunosenescence by life-long caloric restriction. Veterinary Immunology and Immunopathology, 111(3-4), 287-299.

6.5. Kealy, R.D., Olsson, S.E., Monti, K.L., Lawler, D.F., Biery, D.N., Helms, R.W., Lust, G., & Smith, G.K. (1992). Effects of limited food consumption on the incidence of hip dysplasia in growing dogs. Journal of the American Veterinary Medical Association, 201(6), 857-863.

6.6. Kealy, R.D., Lawler, D.F., Ballam, J.M., Lust, G., Smith, G.K., Biery, D.N., & Olsson, S.E. (1997). Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs. Journal of the American Veterinary Medical Association, 210(2), 222-225.

6.7. Larson, B. T., Lawler, D.F., Spitznagel, E. L., & Kealy, R.D. (2003). Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs. Journal of Nutrition, 133(9), 2887-2892.

6.8. Lawler, D.F., Evans, R. H., Larson, B.T., Spitznagel, E. L., Ellersieck, M. R., & Kealy, R. D. (2005). Influence of lifetime food restriction on causes, time, and predictors of death in dogs. Journal of the American Veterinary Medical Association, 226(2), 225-231.

6.9. Lawler, D. F., Ballam, J. M., Meadows, R., Larson, B. T., Li, Q., Stowe, H. D., & Kealy, R. D. (2007). Influence of lifetime food restriction on physiological variables in Labrador retriever dogs. Experimental Gerontology, 42(3), 204-214.

6.10. Lawler, D. F., Larson, B. T., Ballam, J. M., Smith, G. K., Biery, D. N., Evans, R. H., & Kealy, R. D. (2007). Diet restriction and ageing in the dog: major observations over two decades. British Journal of Nutrition, 99(4), 793-805.

6.11. Richards, S. E., Wang, Y., Lawler, D., Kochhar, S., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2008). Self-modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs. Analytic Chemistry Journal, 80(13), 4876-4885.

6.12. Richards, S. E., Wang, Y., Claus, S. P., Lawler, D., Kochhar, S., Holmes, E., & Nicholson, J. K. (2013). Metabolic phenotype modulation by caloric restriction in a lifelong dog study. Journal of Proteome Research, 12(7), 3117-3127.

6.13. Runge, J. J., Biery, D. N., Lawler, D. F., Gregor, T. P., Evans, R. H., Kealy, R. D., Szabo, S. D., & Smith, G. K. (2008). The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder. Veterinary Surgery, 37(1), 102-107.

6.14. Smith, G. K., Lawler, D. F., Biery, D. N., Powers, M. Y., Shofer, F., Gregor, T. P., & Kealy, R. D. (2012). Chronology of hip dysplasia development in a cohort of 48 Labrador retrievers followed for life. Veterinary Surgery, 41(1), 20-33.

6.15. Stowe, H. D., Lawler, D. F., & Kealy, R. D. (2006). Antioxidant status of pair-fed Labrador retrievers is affected by diet restriction and aging. Journal of Nutrition, 136(7), 1844-1848.

6.16. Szabo, S. D., Biery, D. N., Lawler, D. F., Shofer, F. S., Powers, M. Y., Kealy, R. D., & Smith, G. K. (2007). Evaluation of a circumferential femoral head osteophyte as an early indicator of osteoarthritis characteristic of canine hip dysplasia in dogs. Journal of the American Veterinary Medical Association, 231(6), 889-92.

6.17. Wang, Y., Lawler, D., Larson, B., Ramadan, Z., Kochhar, S., Holmes, E., & Nicholson, J. K. (2007). Metabonomic investigations of aging and caloric restriction in a life-long dog study. Journal of Proteome Research, 6(5), 1846-1854.

1. Cupp, C. J., Kerr, W.W., Jean-Philippe, C., Patil, A. R., & Perez-Camargo, G. (2008). The role of nutritional interventions in the longevity and maintenance of long-term health in aging cats. International Journal of Applied Research in Veterinary Medicine, 6(2), 69-81. 

2. Cupp, C. J., & Kerr, W. W. (2010). Effect of diet and body composition on life span in aging cats.  Nestlé Purina Companion Animal Nutrition Summit, Florida, USA, 36-42.

3. Cupp, C. J., Jean-Philippe, C., & Kerr, W. W. (2006). Effect of Nutritional Interventions on Longevity of Senior Cats. International Journal of Applied Research in Veterinary Medicine, 4(1), 34-50.