细胞因子

体重相关状况

犬骨关节炎

成年犬中有五分之一患有骨关节炎，这是一种进展性疼痛性疾病，可降低活动能力和生活质量。¹

在一项具有里程碑意义的研究中，Purina 的研究人员从幼犬时期开始监测 48 只拉布拉多寻回犬的一生健康状况。² 结果表明，从幼犬时期开始采用维持精瘦身体状况的饮食，不仅可延长犬的寿命，还可显著降低犬骨关节炎的患病率。^2-4

在这项研究中，每组中 50% 的犬首次需要长期治疗骨关节炎的平均年龄在精瘦喂养组（13.3 岁）中明显晚于 (P < 0.01) 对照喂养组（10.3 岁）。²

截至 2 岁，精瘦喂养犬的髋关节发育不良发生率比对照组低 50%，且髋关节发育不良的严重程度要低得多。⁵

研究结束时，精瘦喂养组仅 50% 出现髋骨关节炎影像学特征，而对照喂养组则高达 83%。³

维持精瘦身体状况也使得犬到 8 岁时肩骨关节炎和肘骨关节炎的患病率及严重程度分别较低。⁴

Johnston, S. A. (1997). Osteoarthritis: Joint anatomy, physiology, and pathobiology. Veterinary Clinics of North America: Small Animal Practice, 27(4), 699–723.
Kealy, R. D., Lawler, D. F., Ballam, J. M., Mantz, S. L., Biery, D. N., Greeley, E. H., Lust, G., Segre, M., Smith G. K., & Stowe, H. D. (2002). Effects of diet restriction on life span and age-related changes in dogs. Journal of the American Veterinary Medical Association, 220(9), 1315–1320.
Smith, G. K., Paster, E. R., Powers, M. Y., Lawler, D. F., Biery, D. N., Shofer, F. S., McKelvie, P. J., & Kealy, R. D. (2006). Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs. Journal of the American Veterinary Medical Association, 229(5), 690–693.
Kealy, R. D., Lawler, D. F., Ballam, J. M., Lust, G., Biery, D. N., Smith, G. K., & Mantz, S. L. (2000). Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. Journal of the American Veterinary Medical Association, 217(11), 1678–1680.
Kealy, R. D., Olsson, S. E., Monti, K. L., Lawler, D. F., Biery, D. N., Helms, R. W., Lust, G., & Smith, G. K. (1992). Effects of limited food consumption on the incidence of hip dysplasia in growing dogs. Journal of the American Veterinary Medical Association, 201(6), 857–863.