Microbiome-Centric Interventions for Pet Health Conditions

Puppy and kitten

There is increasing evidence that gut microbiome dysbiosis is associated with heart disease.

A targeted nutritional intervention may work through the heart-gut axis to improve cardiac health in pets.

heart valve icon

Putting microbiome science into practice for heart health

dog with heart highlighted icon

Microbiome alterations with heart disease in dogs

The science

Metagenomic analysis showed that dogs with preclinical myxomatous mitral valve disease (MMVD) exhibit gut dysbiosis. The gut dysbiosis index increases in proportion to the severity of the MMVD, and is inversely associated with the abundance of Clostridium hiranonis, which plays a key role in the conversion of primary to secondary bile acids.1

Putting the science into practice

There is a complex relationship between microbiome health and heart health. Dogs with MMVD have an altered microbiome. The microbiota shifts begin at the early preclinical stage before the onset of heart failure, providing an opportunity to address heart disease through the heart-gut axis.

Explore other areas of the Microbiome Forum

microbiome fundamentals

Microbiome Fundamentals

nestle leadership

Nestlé and Purina Leadership in the Microbiome

Find out more

  1. Li, Q., Larouche-Lebel, E., Loughran, K. A., Huh, T. P., Suchodolski, J. S., & Oyama, M. A. (2021). Gut dysbiosis and its associations with gut microbiota-derived metabolites in dogs with myxomatous mitral valve disease. mSystems, 6, e001–1121. doi:10.1128/mSystems.00111-21