Metabolomics
This is the study of small molecules which are the chemical fingerprints resulting from all the biochemical reactions in an organism, from making energy to building proteins. Tracking these metabolites enables researchers to understand metabolism in cells, tissues and the whole body. By discovering which metabolites differ in healthy animals compared to those with disease, Purina’s research can improve understanding about the underlying mechanisms of disease.
Degenerative mitral valve disease
Degenerative mitral valve disease (DMVD) is the most common heart problem in dogs. This condition stresses the heart and may progress to heart failure. Discovering how metabolic pathways are altered in DMVD is an important step in understanding the cellular mechanisms that damage the mitral valve.
Purina's research
Purina scientists used a combination of transcriptomics and metabolomics to study dogs with DMVD. Results identified 54 serum metabolites that differed significantly between healthy and DMVD dogs, including many that indicated abnormal energy metabolism in the diseased group.1,2
Key things to remember
- Small molecules resulting from biochemical reactions are chemical fingerprints that enable researchers to better understand the metabolic differences between healthy pets and those with disease.
- DMVD is one example of a condition where Purina’s metabolomics studies showed how biochemical pathways differ significantly between healthy and DMVD dogs.
Find out more
1. Li, Q., Freeman, L. M., Rush, J. E., Huggins, G. S., Kennedy, A. D., Labuda, J. A., & Hannah, S. S. (2015). Veterinary medicine and multi-omics research for future nutrition targets: metabolomics and transcriptomics of the common degenerative mitral valve disease in dogs. OMICS, 19(8), 461–470.
2. López‐Alvarez, J., Elliott, J., Pfeiffer, D., Chang, Y. M., Mattin, M., Moonarmart, W., & Hezzell, M. J. (2015). Clinical severity score system in dogs with degenerative mitral valve disease. Journal of Veterinary Internal Medicine, 29(2), 575–581.