The gut-associated lymphoid tissue (GALT) of the gastrointestinal tract represents almost 80% of the body’s entire immune system;1 this underscores the critical roles of the gastrointestinal tract and the microbiome in host immunity and defense.
A fine balance between active immunity and immune tolerance is necessary to maintain homeostasis, and disruptions of this balance may contribute to disease.1-4
Supplementing adult dogs’ diets with bovine colostrum bioactives led to greater microbial species diversity, indicating the dogs had stable microbiomes that were more resistant to challenge.5
Feeding a canine diet supplemented with bovine colostrum bioactives may make the microbiome more resistant to infection.
Supplementation with bovine colostrum bioactives resulted in a significant increase in production of antigen-specific IgG in response to canine distemper vaccination as well as more sustained antibody levels, indicating an improved immune response to vaccination.5
Bovine colostrum bioactives improve vaccination response in dogs.
Kittens supplemented with bovine colostrum bioactives showed increased and sustained antibody response to the rabies vaccine.6
Bovine colostrum bioactives improve vaccination response in kittens.
The probiotic strain Enterococcus faecium SF68 enhanced IgA and IgG production as well as monocyte activation in growing dogs but did not induce overstimulation of the immune system.7,8
The probiotic strain E. faecium SF68 may increase priming of naïve B cells in response to initial canine distemper virus vaccination, which may enhance the effectiveness of the vaccine in preventing infection.7,8
The probiotic E. faecium SF68 improves vaccine response and long-term immune functions in growing dogs without overstimulating the immune system.
Cats with latent herpesvirus infections showed significantly fewer observation points with conjunctivitis when supplemented with E. faecium SF68 as compared to cats in the placebo group.8,10
The probiotic strain E. faecium SF68 may improve the clinical course of latent feline herpesvirus in cats.
Shelter cats receiving Bacillus coagulans GBI-30 6086 (BC30) showed a numerical decrease in the number of days with clinical signs of upper respiratory tract disease.11
The probiotic strain Bacillus coagulans GBI-30 6086 (BC30) may help reduce upper respiratory tract disease in shelter cats.
Some heat-killed strains of Lactobacillus species can produce immunomodulatory effects equal to live strains.12 A heat-treated blend of Lactobacillus fermentum and Lactobacillus delbrueckii increased fecal IgA antibody levels in response to rabies vaccination, indicating an enhanced immune response.11
Effective paraprobiotics may provide immunomodulatory benefits despite the lack of live bacteria.