Mechanisms of Sarcopenia and Regenerative Decline During Aging of Skeletal Muscle

Jerome N. Feige, PhD
Nestlé Institute of Health Sciences



  • Sarcopenia is a multifactorial condition, impacted by genetics, metabolic changes, exercise/activity levels and nutrition.
  • Physical activity, exercise, and nutrition are all important in preventing and managing sarcopenia.
  • The progression of sarcopenia has been associated with diets low in protein and vitamin B12 (cobalamin).
  • Future research will focus on better defining sarcopenia and exploring both pharmacological and nutritional interventions.



Jerome N. Feige, PhD- Nestlé Institute of Health Sciences

Dr. Jerome Feige holds a master’s degree in bioengineering from the National Institute of Applied Sciences in Lyon, France, and a doctorate degree in biology from the University of Lausanne, where he studied the molecular mechanisms of lipid sensing through PPAR nuclear receptors at the Center for Integrative Genomics with Profs Wahli and Desvergne.His postdoctoral research training was with Prof Johan Auwerx at the Institute of Genetics and Molecular and Cellular Biology in Strasbourg, France, where he studied the mechanisms of energy sensing by Sirt1 and demonstrated the beneficial effects of targeting Sirt1 on metabolic diseases.

From 2007 to 2012, Dr. Feige led a laboratory that studied therapeutic drugs for treating muscle diseases at Novartis in Basel, Switzerland. He returned to Lausanne in 2012 to create the Muscle and Aging Group at the newly founded Nestlé Institute of Health Sciences. Dr. Feige leads a discovery and translational research program that focuses on the molecular and nutritional mechanisms of muscle growth and sarcopenia. In addition, he holds an adjunct assistant professorship at Ecole Polytechnique Federale de Lausanne, where he teaches an undergraduate course on global issues in food and nutrition and trains and mentors graduate and doctorate students on muscle research.